Investigation of the effect of quercetin in an experimental oxygen-induced retinopathy model

Aim: Investigation of the effect intraperitoneal (IP) quercetin and bevacizumab on oxygen-induced retinopathy (OIR) model in rats. Methods: In study, 28 newborn rats were used. The OIR was performed with 50/10% oxygen technique. study consisted four groups as a control group (Group I) II, III, IV). IP injection applied to all postnatal day (PND) 14. Groups I II 0.9% NaCl, Group III bevacizumab, IV quercetin. All animals sacrificed PND 18. Results: Based data obtained from immunohistochemical histopathological examinations, number vascular endothelial cell (VEC), growth factor (VEGF), tumor necrosis factor-α (TNF-α) levels significantly reduced compared II. VECs 0±0, 32.69±5.77, 2.92±0.63, 3.64±0.36 I, IV, respectively (p<0.001). Likewise, VEGF values 0.15±0.01, 7.57±1.80, 2.45±0.45, 2.46±0.49, As well TNF-α 0.06±0.01, 8.22±2.24, 2.32±0.32, 2.29±0.26 There no significant difference between terms VEC, (range p 0.96-1.00). Conclusion: results present showed that administration VEC suppressed TNF-α. Quercetin's anti-inflammatory anti-angiogenesis found be similar bevacizumab.